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RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability
DNA topoisomerase I (TOP1) has an important role in maintaining DNA topology by relaxing supercoiled DNA. Here we show that the K391 and K436 residues of TOP1 are SUMOylated by the PIAS1–SRSF1 E3 ligase complex in the chromatin fraction containing active RNA polymerase II (RNAPIIo). This modificatio...
में बचाया:
| में प्रकाशित: | Nat Commun |
|---|---|
| मुख्य लेखकों: | , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2015
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7553879/ https://ncbi.nlm.nih.gov/pubmed/25851487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7720 |
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