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PIASy-dependent SUMOylation regulates DNA topoisomerase IIα activity

DNA topoisomerase IIα (TopoIIα) is an essential chromosome-associated enzyme with activity implicated in the resolution of tangled DNA at centromeres before anaphase onset. However, the regulatory mechanism of TopoIIα activity is not understood. Here, we show that PIASy-mediated small ubiquitin-like...

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Detalhes bibliográficos
Main Authors: Ryu, Hyunju, Furuta, Maiko, Kirkpatrick, Donald, Gygi, Steven P., Azuma, Yoshiaki
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2983052/
https://ncbi.nlm.nih.gov/pubmed/21079245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201004033
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