PIASy-dependent SUMOylation regulates DNA topoisomerase IIα activity

DNA topoisomerase IIα (TopoIIα) is an essential chromosome-associated enzyme with activity implicated in the resolution of tangled DNA at centromeres before anaphase onset. However, the regulatory mechanism of TopoIIα activity is not understood. Here, we show that PIASy-mediated small ubiquitin-like...

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Библиографические подробности
Главные авторы: Ryu, Hyunju, Furuta, Maiko, Kirkpatrick, Donald, Gygi, Steven P., Azuma, Yoshiaki
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2010
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Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2983052/
https://ncbi.nlm.nih.gov/pubmed/21079245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201004033
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