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PIASy-dependent SUMOylation regulates DNA topoisomerase IIα activity
DNA topoisomerase IIα (TopoIIα) is an essential chromosome-associated enzyme with activity implicated in the resolution of tangled DNA at centromeres before anaphase onset. However, the regulatory mechanism of TopoIIα activity is not understood. Here, we show that PIASy-mediated small ubiquitin-like...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2983052/ https://ncbi.nlm.nih.gov/pubmed/21079245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201004033 |
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