SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin

DNA topoisomerase II (TopoII) regulates DNA topology by its strand passaging reaction, which is required for genome maintenance by resolving tangled genomic DNA. In addition, TopoII contributes to the structural integrity of mitotic chromosomes and to the activation of cell cycle checkpoints in mito...

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Publicat a:Cell Cycle
Autors principals: Ryu, Hyunju, Yoshida, Makoto M, Sridharan, Vinidhra, Kumagai, Akiko, Dunphy, William G, Dasso, Mary, Azuma, Yoshiaki
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
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Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614044/
https://ncbi.nlm.nih.gov/pubmed/26131587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1066537
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