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SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin

DNA topoisomerase II (TopoII) regulates DNA topology by its strand passaging reaction, which is required for genome maintenance by resolving tangled genomic DNA. In addition, TopoII contributes to the structural integrity of mitotic chromosomes and to the activation of cell cycle checkpoints in mito...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Ryu, Hyunju, Yoshida, Makoto M, Sridharan, Vinidhra, Kumagai, Akiko, Dunphy, William G, Dasso, Mary, Azuma, Yoshiaki
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614044/
https://ncbi.nlm.nih.gov/pubmed/26131587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1066537
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