SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin

DNA topoisomerase II (TopoII) regulates DNA topology by its strand passaging reaction, which is required for genome maintenance by resolving tangled genomic DNA. In addition, TopoII contributes to the structural integrity of mitotic chromosomes and to the activation of cell cycle checkpoints in mito...

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Veröffentlicht in:Cell Cycle
Hauptverfasser: Ryu, Hyunju, Yoshida, Makoto M, Sridharan, Vinidhra, Kumagai, Akiko, Dunphy, William G, Dasso, Mary, Azuma, Yoshiaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614044/
https://ncbi.nlm.nih.gov/pubmed/26131587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1066537
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