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RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability

DNA topoisomerase I (TOP1) has an important role in maintaining DNA topology by relaxing supercoiled DNA. Here we show that the K391 and K436 residues of TOP1 are SUMOylated by the PIAS1–SRSF1 E3 ligase complex in the chromatin fraction containing active RNA polymerase II (RNAPIIo). This modificatio...

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Pubblicato in:Nat Commun
Autori principali: Li, Min, Pokharel, Subhash, Wang, Jiin-Tarng, Xu, Xiaohua, Liu, Yilun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553879/
https://ncbi.nlm.nih.gov/pubmed/25851487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7720
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