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Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction
Mitochondrial DNA (mtDNA) encodes genes important for ATP biogenesis. Therefore, changes in mtDNA copy number will have profound consequences on cell survival and proliferation. RECQ4 DNA helicase plays important roles in both nuclear and mtDNA synthesis. However, the mechanism that balances the dis...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4029353/ https://ncbi.nlm.nih.gov/pubmed/24746816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.03.037 |
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