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Telomere Dysfunction Drives Increased Mutation by Error-Prone Polymerases Rev1 and ζ in Saccharomyces cerevisiae
Using a model system, we have shown that replicative senescence is accompanied by a 16-fold increase in base substitution and frameshift mutations near a chromosome end. The increase was dependent on error-prone polymerases required for the mutagenic response to DNA lesions that block the replicatio...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
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Copyright © 2007 by the Genetics Society of America
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1840081/ https://ncbi.nlm.nih.gov/pubmed/17151233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.068130 |
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