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Role of Dot1 in the Response to Alkylating DNA Damage in Saccharomyces cerevisiae: Regulation of DNA Damage Tolerance by the Error-Prone Polymerases Polζ/Rev1

Maintenance of genomic integrity relies on a proper response to DNA injuries integrated by the DNA damage checkpoint; histone modifications play an important role in this response. Dot1 methylates lysine 79 of histone H3. In Saccharomyces cerevisiae, Dot1 is required for the meiotic recombination ch...

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Detalhes bibliográficos
Main Authors: Conde, Francisco, San-Segundo, Pedro A.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475726/
https://ncbi.nlm.nih.gov/pubmed/18562671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.089003
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