Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

Topoisomerase I (Top1) is a key enzyme acting at the interface between DNA replication, transcription and mRNA maturation. Here, we show that Top1 suppresses genomic instability in mammalian cells by preventing conflicts between transcription and DNA replication. Using DNA combing and ChIP-on-chip,...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Tuduri, Sandie, Crabbé, Laure, Conti, Chiara, Tourrière, Hélène, Holtgreve-Grez, Heidi, Jauch, Anna, Pantesco, Véronique, De Vos, John, Thomas, Aubin, Theillet, Charles, Pommier, Yves, Tazi, Jamal, Coquelle, Arnaud, Pasero, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Macmillan Magazines Ltd 2009
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912930/
https://ncbi.nlm.nih.gov/pubmed/19838172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1984
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados