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Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription
Topoisomerase I (Top1) is a key enzyme acting at the interface between DNA replication, transcription and mRNA maturation. Here, we show that Top1 suppresses genomic instability in mammalian cells by preventing conflicts between transcription and DNA replication. Using DNA combing and ChIP-on-chip,...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Macmillan Magazines Ltd
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2912930/ https://ncbi.nlm.nih.gov/pubmed/19838172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1984 |
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