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Telomere dysfunction as a cause of genomic instability in Werner syndrome

Werner syndrome (WS) is a rare human premature aging disease caused by mutations in the gene encoding the RecQ helicase WRN. In addition to the aging features, this disorder is marked by genomic instability, associated with an elevated incidence of cancer. Several lines of evidence suggest that telo...

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Bibliografiska uppgifter
Huvudupphovsmän: Crabbe, Laure, Jauch, Anna, Naeger, Colleen M., Holtgreve-Grez, Heidi, Karlseder, Jan
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2007
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1794219/
https://ncbi.nlm.nih.gov/pubmed/17284601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609410104
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