New Topoisomerase I mutations are associated with resistance to camptothecin

BACKGROUND: Topoisomerase I (TOP1) is a nuclear enzyme that catalyzes the relaxation of supercoiled DNA during DNA replication and transcription. TOP1 is the molecular target of camptothecin and related drugs such as irinotecan and SN38 (irinotecan's active metabolite). Irinotecan is widely use...

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Detalhes bibliográficos
Main Authors: Gongora, Céline, Vezzio-Vie, Nadia, Tuduri, Sandie, Denis, Vincent, Causse, Annick, Auzanneau, Céline, Collod-Beroud, Gwenaëlle, Coquelle, Arnaud, Pasero, Philippe, Pourquier, Philippe, Martineau, Pierre, Del Rio, Maguy
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3120799/
https://ncbi.nlm.nih.gov/pubmed/21619602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-64
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