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New Topoisomerase I mutations are associated with resistance to camptothecin
BACKGROUND: Topoisomerase I (TOP1) is a nuclear enzyme that catalyzes the relaxation of supercoiled DNA during DNA replication and transcription. TOP1 is the molecular target of camptothecin and related drugs such as irinotecan and SN38 (irinotecan's active metabolite). Irinotecan is widely use...
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| Glavni autori: | , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3120799/ https://ncbi.nlm.nih.gov/pubmed/21619602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-64 |
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