MAPK14/p38α confers irinotecan resistance to TP53-defective cells by inducing survival autophagy

Recently we have shown that the mitogen-activated protein kinase (MAPK) MAPK14/p38α is involved in resistance of colon cancer cells to camptothecin-related drugs. Here we further investigated the cellular mechanisms involved in such drug resistance and showed that, in HCT116 human colorectal adenoca...

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Bibliografiske detaljer
Main Authors: Paillas, Salome, Causse, Annick, Marzi, Laetitia, de Medina, Philippe, Poirot, Marc, Denis, Vincent, Vezzio-Vie, Nadia, Espert, Lucile, Arzouk, Hayat, Coquelle, Arnaud, Martineau, Pierre, Del Rio, Maguy, Pattingre, Sophie, Gongora, Céline
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Basic Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429546/
https://ncbi.nlm.nih.gov/pubmed/22647487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.20268
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