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TAp63α targeting of Lgr5 mediates colorectal cancer stem cell properties and sulforaphane inhibition

Cancer stem cells (CSCs) have an established role in cancer progression and therapeutic resistance. The p63 proteins are important transcription factors which belong to the p53 family, but their function and mechanism in CSCs remain elusive. Here, we investigated the role of TAp63α in colorectal CSC...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Oncogenesis
Päätekijät: Chen, Yue, Wang, Meng-huan, Zhu, Jian-yun, Xie, Chun-feng, Li, Xiao-ting, Wu, Jie-shu, Geng, Shan-shan, Han, Hong-yu, Zhong, Cai-yun
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7548006/
https://ncbi.nlm.nih.gov/pubmed/33040081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-00273-z
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