TAp63α targeting of Lgr5 mediates colorectal cancer stem cell properties and sulforaphane inhibition

Cancer stem cells (CSCs) have an established role in cancer progression and therapeutic resistance. The p63 proteins are important transcription factors which belong to the p53 family, but their function and mechanism in CSCs remain elusive. Here, we investigated the role of TAp63α in colorectal CSC...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncogenesis
Prif Awduron: Chen, Yue, Wang, Meng-huan, Zhu, Jian-yun, Xie, Chun-feng, Li, Xiao-ting, Wu, Jie-shu, Geng, Shan-shan, Han, Hong-yu, Zhong, Cai-yun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7548006/
https://ncbi.nlm.nih.gov/pubmed/33040081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-00273-z
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