Dietary thiamine influences l-asparaginase sensitivity in a subset of leukemia cells

Tumor environment influences anticancer therapy response but which extracellular nutrients affect drug sensitivity is largely unknown. Using functional genomics, we determine modifiers of l-asparaginase (ASNase) response and identify thiamine pyrophosphate kinase 1 as a metabolic dependency under AS...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Guarecuco, Rohiverth, Williams, Robert T., Baudrier, Lou, La, Konnor, Passarelli, Maria C., Ekizoglu, Naz, Mestanoglu, Mert, Alwaseem, Hanan, Rostandy, Bety, Fidelin, Justine, Garcia-Bermudez, Javier, Molina, Henrik, Birsoy, Kıvanç
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7546708/
https://ncbi.nlm.nih.gov/pubmed/33036978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc7120
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados