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Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

Cancer cells rewire their metabolism and rely on endogenous antioxidants to mitigate lethal oxidative damage to lipids. However, the metabolic processes which modulate the response to lipid peroxidation are poorly defined. Using genetic screens, we compared metabolic genes essential for proliferatio...

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Bibliografski detalji
Izdano u:Nat Chem Biol
Glavni autori: Soula, Mariluz, Weber, Ross A., Zilka, Omkar, Alwaseem, Hanan, La, Konnor, Yen, Frederick, Molina, Henrik, Garcia-Bermudez, Javier, Pratt, Derek A., Birsoy, Kıvanç
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8299533/
https://ncbi.nlm.nih.gov/pubmed/32778843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0613-y
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