Dietary thiamine influences l-asparaginase sensitivity in a subset of leukemia cells

Tumor environment influences anticancer therapy response but which extracellular nutrients affect drug sensitivity is largely unknown. Using functional genomics, we determine modifiers of l-asparaginase (ASNase) response and identify thiamine pyrophosphate kinase 1 as a metabolic dependency under AS...

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Udgivet i:Sci Adv
Main Authors: Guarecuco, Rohiverth, Williams, Robert T., Baudrier, Lou, La, Konnor, Passarelli, Maria C., Ekizoglu, Naz, Mestanoglu, Mert, Alwaseem, Hanan, Rostandy, Bety, Fidelin, Justine, Garcia-Bermudez, Javier, Molina, Henrik, Birsoy, Kıvanç
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7546708/
https://ncbi.nlm.nih.gov/pubmed/33036978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc7120
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