Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

Cholesterol is essential for cells to grow and proliferate. While normal mammalian cells meet their need for cholesterol through its uptake or de novo synthesis(1), the extent to which cancer cells rely on each of these pathways remains poorly understood. Here, using a competitive proliferation assa...

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Bibliografske podrobnosti
izdano v:Nature
Main Authors: Garcia-Bermudez, Javier, Baudrier, Lou, Can Bayraktar, Erol, Shen, Yihui, La, Konnor, Guarecuco, Rohiverth, Yucel, Burcu, Fiore, Danilo, Tavora, Bernardo, Freinkman, Elizaveta, Ham Chan, Sze, Lewis, Caroline, Min, Wei, Inghirami, Giorgio, Sabatini, David M, Birsoy, Kıvanç
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6405297/
https://ncbi.nlm.nih.gov/pubmed/30760928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-0945-5
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