Glutamate dehydrogenase as a biomarker for mitotoxicity; insights from furosemide hepatotoxicity in the mouse

Glutamate dehydrogenase (GLDH) is a liver-specific biomarker of hepatocellular damage currently undergoing qualification as a drug development tool. Since GLDH is located within the mitochondrial matrix, it has been hypothesized that it might also be useful in assessing mitotoxicity as an initiating...

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Pubblicato in:PLoS One
Autori principali: Church, Rachel J., Schomaker, Shelli J., Eaddy, J. Scott, Boucher, Germaine G., Kreeger, John M., Aubrecht, Jiri, Watkins, Paul B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7546462/
https://ncbi.nlm.nih.gov/pubmed/33035276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0240562
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