Modulation of Major Human Liver Microsomal Cytochromes P450 by Component Alkaloids of Goldenseal: Time-Dependent Inhibition and Allosteric Effects

Botanical and other natural products (NPs) are often coconsumed with prescription medications, presenting a risk for cytochrome P450 (P450)-mediated NP-drug interactions. The NP goldenseal (Hydrastis canadensis) has exhibited antimicrobial activities in vitro attributed to isoquinoline alkaloids con...

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Enregistré dans:
Détails bibliographiques
Publié dans:Drug Metab Dispos
Auteurs principaux: McDonald, Matthew G., Tian, Dan-Dan, Thummel, Kenneth E., Paine, Mary F., Rettie, Allan E.
Format: Artigo
Langue:Inglês
Publié: The American Society for Pharmacology and Experimental Therapeutics 2020
Sujets:
Special Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543482/
https://ncbi.nlm.nih.gov/pubmed/32591416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.091041
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