Modulation of Major Human Liver Microsomal Cytochromes P450 by Component Alkaloids of Goldenseal: Time-Dependent Inhibition and Allosteric Effects

Botanical and other natural products (NPs) are often coconsumed with prescription medications, presenting a risk for cytochrome P450 (P450)-mediated NP-drug interactions. The NP goldenseal (Hydrastis canadensis) has exhibited antimicrobial activities in vitro attributed to isoquinoline alkaloids con...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Drug Metab Dispos
Prif Awduron: McDonald, Matthew G., Tian, Dan-Dan, Thummel, Kenneth E., Paine, Mary F., Rettie, Allan E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2020
Pynciau:
Special Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543482/
https://ncbi.nlm.nih.gov/pubmed/32591416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.091041
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