Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450

Cannabis is used for both recreational and medicinal purposes. The most abundant constituents are the cannabinoids - cannabidiol (CBD, nonpsychoactive) and (−)-trans-Δ(9)-tetrahydrocannabinol (THC, psychoactive). Both have been reported to reversibly inhibit or inactivate cytochrome P450 (CYPs) enzy...

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Veröffentlicht in:Drug Metab Dispos
Hauptverfasser: Bansal, Sumit, Maharao, Neha, Paine, Mary F., Unadkat, Jashvant D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2020
Schlagworte:
Special Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543485/
https://ncbi.nlm.nih.gov/pubmed/32587099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.000073
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