Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450

Cannabis is used for both recreational and medicinal purposes. The most abundant constituents are the cannabinoids - cannabidiol (CBD, nonpsychoactive) and (−)-trans-Δ(9)-tetrahydrocannabinol (THC, psychoactive). Both have been reported to reversibly inhibit or inactivate cytochrome P450 (CYPs) enzy...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Bansal, Sumit, Maharao, Neha, Paine, Mary F., Unadkat, Jashvant D.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2020
Assuntos:
Special Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543485/
https://ncbi.nlm.nih.gov/pubmed/32587099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.000073
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