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Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450

Cannabis is used for both recreational and medicinal purposes. The most abundant constituents are the cannabinoids - cannabidiol (CBD, nonpsychoactive) and (−)-trans-Δ(9)-tetrahydrocannabinol (THC, psychoactive). Both have been reported to reversibly inhibit or inactivate cytochrome P450 (CYPs) enzy...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Drug Metab Dispos
Main Authors: Bansal, Sumit, Maharao, Neha, Paine, Mary F., Unadkat, Jashvant D.
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Pharmacology and Experimental Therapeutics 2020
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543485/
https://ncbi.nlm.nih.gov/pubmed/32587099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.000073
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