Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450

Cannabis is used for both recreational and medicinal purposes. The most abundant constituents are the cannabinoids - cannabidiol (CBD, nonpsychoactive) and (−)-trans-Δ(9)-tetrahydrocannabinol (THC, psychoactive). Both have been reported to reversibly inhibit or inactivate cytochrome P450 (CYPs) enzy...

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Détails bibliographiques
Publié dans:Drug Metab Dispos
Auteurs principaux: Bansal, Sumit, Maharao, Neha, Paine, Mary F., Unadkat, Jashvant D.
Format: Artigo
Langue:Inglês
Publié: The American Society for Pharmacology and Experimental Therapeutics 2020
Sujets:
Special Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543485/
https://ncbi.nlm.nih.gov/pubmed/32587099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.000073
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