Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes

AIMS: Albendazole (ABZ; methyl 5-propylthio-1H-benzimidazol-2-yl carbamate) is a broad spectrum anthelmintic whose activity resides both in the parent compound and its sulphoxide metabolite (ABS). There are numerous reports of ABZ metabolism in animals but relatively few in humans. We have investiga...

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Main Authors: Rawden, Helen C, Kokwaro, Gilbert O, Ward, Stephen A, Edwards, Geoffrey
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2000
Fag:
Drug Disposition
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014938/
https://ncbi.nlm.nih.gov/pubmed/10759686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00170.x
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