Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes

AIMS: Albendazole (ABZ; methyl 5-propylthio-1H-benzimidazol-2-yl carbamate) is a broad spectrum anthelmintic whose activity resides both in the parent compound and its sulphoxide metabolite (ABS). There are numerous reports of ABZ metabolism in animals but relatively few in humans. We have investiga...

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Detalhes bibliográficos
Main Authors: Rawden, Helen C, Kokwaro, Gilbert O, Ward, Stephen A, Edwards, Geoffrey
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2000
Assuntos:
Drug Disposition
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014938/
https://ncbi.nlm.nih.gov/pubmed/10759686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00170.x
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