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In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms

AIMS: To determine the FMO and P450 isoform selectivity for metabolism of benzydamine and caffeine, two potential in vivo probes for human FMO. METHODS: Metabolic incubations were conducted at physiological pH using substrate concentrations of 0.01–10 mm with either recombinant human FMOs, P450s or...

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Autori principali: Lang, Dieter H, Rettie, Allan E
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014993/
https://ncbi.nlm.nih.gov/pubmed/11012553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00265.x
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