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In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms
AIMS: To determine the FMO and P450 isoform selectivity for metabolism of benzydamine and caffeine, two potential in vivo probes for human FMO. METHODS: Metabolic incubations were conducted at physiological pH using substrate concentrations of 0.01–10 mm with either recombinant human FMOs, P450s or...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2000
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2014993/ https://ncbi.nlm.nih.gov/pubmed/11012553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00265.x |
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