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Mammalian Flavin-Containing Monooxygenase (FMO) as a Source of Hydrogen Peroxide
Flavin-containing monooxygenase (FMO) oxygenates drugs/xenobiotics containing a soft nucleophile through a C4a hydroperoxy-FAD intermediate. Human FMOs 1, 2 and 3, expressed in Sf9 insect microsomes, released 30–50% of O(2) consumed as H(2)O(2) upon addition of NADPH. Addition of substrate had littl...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4116332/ https://ncbi.nlm.nih.gov/pubmed/24561181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.02.006 |
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