Flavin-Containing Monooxygenase S-Oxygenation of a Series of Thioureas and Thiones

Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second ti...

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Main Authors: Henderson, Marilyn C., Siddens, Lisbeth K., Krueger, Sharon K., Stevens, J. Fred, Kedzie, Karen, Fang, Ken, Heidelbaugh, Todd, Nguyen, Phong, Chow, Ken, Garst, Michael, Gil, Daniel, Williams, David E.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110205/
https://ncbi.nlm.nih.gov/pubmed/24727368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2014.04.002
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