Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes

AIMS: Albendazole (ABZ; methyl 5-propylthio-1H-benzimidazol-2-yl carbamate) is a broad spectrum anthelmintic whose activity resides both in the parent compound and its sulphoxide metabolite (ABS). There are numerous reports of ABZ metabolism in animals but relatively few in humans. We have investiga...

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Bibliografski detalji
Glavni autori: Rawden, Helen C, Kokwaro, Gilbert O, Ward, Stephen A, Edwards, Geoffrey
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2000
Teme:
Drug Disposition
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014938/
https://ncbi.nlm.nih.gov/pubmed/10759686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00170.x
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