Dynamics of Staphylococcus aureus Cas9 in DNA target Association and Dissociation

Staphylococcus aureus Cas9 (SaCas9) is an RNA‐guided endonuclease that targets complementary DNA adjacent to a protospacer adjacent motif (PAM) for cleavage. Its small size facilitates in vivo delivery for genome editing in various organisms. Herein, using single‐molecule and ensemble approaches, we...

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Pubblicato in:EMBO Rep
Autori principali: Zhang, Siqi, Zhang, Qian, Hou, Xi‐Miao, Guo, Lijuan, Wang, Fangzhu, Bi, Lulu, Zhang, Xia, Li, Hai‐Hong, Wen, Fengcai, Xi, Xu‐Guang, Huang, Xingxu, Shen, Bin, Sun, Bo
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534634/
https://ncbi.nlm.nih.gov/pubmed/32790142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050184
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