Crystal structure of Staphylococcus aureus Cas9

The RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA targets with a protospacer adjacent motif (PAM) and complementarity to the guide RNA. Recently, we harnessed Staphylococcus aureus Cas9 (SaCas9), which is significantly smaller than Streptococcus pyogenes Cas9 (SpCas9), to facilitate e...

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Bibliografiske detaljer
Udgivet i:Cell
Main Authors: Nishimasu, Hiroshi, Cong, Le, Yan, Winston X., Ran, F. Ann, Zetsche, Bernd, Li, Yinqing, Kurabayashi, Arisa, Ishitani, Ryuichiro, Zhang, Feng, Nureki, Osamu
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670267/
https://ncbi.nlm.nih.gov/pubmed/26317473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.08.007
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