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The post-PAM interaction of RNA-guided spCas9 with DNA dictates its target binding and dissociation
Cas9 is an RNA-guided endonuclease that targets complementary DNA for cleavage and has been repurposed for many biological usages. Cas9 activities are governed by its direct interactions with DNA. However, information about this interplay and the mechanism involved in its direction of Cas9 activity...
Uloženo v:
| Vydáno v: | Sci Adv |
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| Hlavní autoři: | , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Association for the Advancement of Science
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6853773/ https://ncbi.nlm.nih.gov/pubmed/31763447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw9807 |
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