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The post-PAM interaction of RNA-guided spCas9 with DNA dictates its target binding and dissociation
Cas9 is an RNA-guided endonuclease that targets complementary DNA for cleavage and has been repurposed for many biological usages. Cas9 activities are governed by its direct interactions with DNA. However, information about this interplay and the mechanism involved in its direction of Cas9 activity...
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| 出版年: | Sci Adv |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Association for the Advancement of Science
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6853773/ https://ncbi.nlm.nih.gov/pubmed/31763447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw9807 |
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