Coevolutionary Couplings Unravel PAM-Proximal Constraints of CRISPR-SpCas9

The clustered regularly interspaced short palindromic repeats (CRISPR) system, an immune system analog found in prokaryotes, allows a single-guide RNA to direct a CRISPR-associated protein (Cas) with combined helicase and nuclease activity to DNA. The presence of a specific protospacer adjacent moti...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Li, Yi, De la Paz, José A., Jiang, Xianli, Liu, Richard, Pokkulandra, Adarsha P., Bleris, Leonidas, Morcos, Faruck
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2019
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838953/
https://ncbi.nlm.nih.gov/pubmed/31648792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.09.040
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