Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

Diffuse large B-cell lymphomas (DLBCLs) are genetically heterogeneous and highly proliferative neoplasms derived from germinal center (GC) B-cells. Herein, we show that DLBCLs are dependent on mitochondrial lysine deacetylase SIRT3 for proliferation, survival, self-renewal, and tumor growth in vivo...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cancer Cell
Päätekijät: Li, Meng, Chiang, Ying-Ling, Lyssiotis, Costas A., Teater, Matthew R., Hong, Jun Young, Shen, Hao, Wang, Ling, Hu, Jing, Jing, Hui, Chen, Zhengming, Jain, Neeraj, Duy, Cihangir, Mistry, Sucharita J., Cerchietti, Leandro, Cross, Justin R., Cantley, Lewis C., Green, Michael R., Lin, Hening, Melnick, Ari M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534582/
https://ncbi.nlm.nih.gov/pubmed/31185214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.05.002
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