Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

Diffuse large B-cell lymphomas (DLBCLs) are genetically heterogeneous and highly proliferative neoplasms derived from germinal center (GC) B-cells. Herein, we show that DLBCLs are dependent on mitochondrial lysine deacetylase SIRT3 for proliferation, survival, self-renewal, and tumor growth in vivo...

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Dades bibliogràfiques
Publicat a:Cancer Cell
Autors principals: Li, Meng, Chiang, Ying-Ling, Lyssiotis, Costas A., Teater, Matthew R., Hong, Jun Young, Shen, Hao, Wang, Ling, Hu, Jing, Jing, Hui, Chen, Zhengming, Jain, Neeraj, Duy, Cihangir, Mistry, Sucharita J., Cerchietti, Leandro, Cross, Justin R., Cantley, Lewis C., Green, Michael R., Lin, Hening, Melnick, Ari M.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534582/
https://ncbi.nlm.nih.gov/pubmed/31185214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.05.002
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