Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

Diffuse large B-cell lymphomas (DLBCLs) are genetically heterogeneous and highly proliferative neoplasms derived from germinal center (GC) B-cells. Herein, we show that DLBCLs are dependent on mitochondrial lysine deacetylase SIRT3 for proliferation, survival, self-renewal, and tumor growth in vivo...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Li, Meng, Chiang, Ying-Ling, Lyssiotis, Costas A., Teater, Matthew R., Hong, Jun Young, Shen, Hao, Wang, Ling, Hu, Jing, Jing, Hui, Chen, Zhengming, Jain, Neeraj, Duy, Cihangir, Mistry, Sucharita J., Cerchietti, Leandro, Cross, Justin R., Cantley, Lewis C., Green, Michael R., Lin, Hening, Melnick, Ari M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534582/
https://ncbi.nlm.nih.gov/pubmed/31185214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.05.002
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