An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells

The oxygen transport function of hemoglobin (HB) is thought to have arisen ∼500 million years ago, roughly coinciding with the divergence between jawless (Agnatha) and jawed (Gnathostomata) vertebrates. Intriguingly, extant HBs of jawless and jawed vertebrates were shown to have evolved twice, and i...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Miyata, Masato, Gillemans, Nynke, Hockman, Dorit, Demmers, Jeroen A. A., Cheng, Jan-Fang, Hou, Jun, Salminen, Matti, Fisher, Christopher A., Taylor, Stephen, Gibbons, Richard J., Ganis, Jared J., Zon, Leonard I., Grosveld, Frank, Mulugeta, Eskeatnaf, Sauka-Spengler, Tatjana, Higgs, Douglas R., Philipsen, Sjaak
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2020
Schlagworte:
Plenary Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7531998/
https://ncbi.nlm.nih.gov/pubmed/32396940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020004826
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