The active spatial organization of the β-globin locus requires the transcription factor EKLF

Three-dimensional organization of a gene locus is important for its regulation, as recently demonstrated for the β-globin locus. When actively expressed, the cis-regulatory elements of the β-globin locus are in proximity in the nuclear space, forming a compartment termed the Active Chromatin Hub (AC...

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Detalles Bibliográficos
Publicado en:Genes Dev
Main Authors: Drissen, Roy, Palstra, Robert-Jan, Gillemans, Nynke, Splinter, Erik, Grosveld, Frank, Philipsen, Sjaak, de Laat, Wouter
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Research Communications
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC529536/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15489291/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.317004
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