The active spatial organization of the β-globin locus requires the transcription factor EKLF

Three-dimensional organization of a gene locus is important for its regulation, as recently demonstrated for the β-globin locus. When actively expressed, the cis-regulatory elements of the β-globin locus are in proximity in the nuclear space, forming a compartment termed the Active Chromatin Hub (AC...

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Bibliographic Details
Main Authors: Drissen, Roy, Palstra, Robert-Jan, Gillemans, Nynke, Splinter, Erik, Grosveld, Frank, Philipsen, Sjaak, de Laat, Wouter
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2004
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC529536/
https://ncbi.nlm.nih.gov/pubmed/15489291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.317004
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