CTCF mediates long-range chromatin looping and local histone modification in the β-globin locus

CTCF (CCCTC-binding factor) binds sites around the mouse β-globin locus that spatially cluster in the erythroid cell nucleus. We show that both conditional deletion of CTCF and targeted disruption of a DNA-binding site destabilize these long-range interactions and cause local loss of histone acetyla...

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Autori principali: Splinter, Erik, Heath, Helen, Kooren, Jurgen, Palstra, Robert-Jan, Klous, Petra, Grosveld, Frank, Galjart, Niels, de Laat, Wouter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2006
Soggetti:
Research Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1560409/
https://ncbi.nlm.nih.gov/pubmed/16951251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.399506
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