Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the β-globin locus control region in vivo

The locus control region of the β-globin cluster contains five DNase I hypersensitive sites (5′HS1–5) required for locus activation. 5′HS3 contains six G-rich motifs that are essential for its activity. Members of a protein family, characterized by three zinc fingers highly homologous to those found...

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Autors principals: Gillemans, Nynke, Tewari, Rita, Lindeboom, Fokke, Rottier, Robbert, de Wit, Ton, Wijgerde, Mark, Grosveld, Frank, Philipsen, Sjaak
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 1998
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Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC317172/
https://ncbi.nlm.nih.gov/pubmed/9744863
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