An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells

The oxygen transport function of hemoglobin (HB) is thought to have arisen ∼500 million years ago, roughly coinciding with the divergence between jawless (Agnatha) and jawed (Gnathostomata) vertebrates. Intriguingly, extant HBs of jawless and jawed vertebrates were shown to have evolved twice, and i...

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Published in:Blood
Main Authors: Miyata, Masato, Gillemans, Nynke, Hockman, Dorit, Demmers, Jeroen A. A., Cheng, Jan-Fang, Hou, Jun, Salminen, Matti, Fisher, Christopher A., Taylor, Stephen, Gibbons, Richard J., Ganis, Jared J., Zon, Leonard I., Grosveld, Frank, Mulugeta, Eskeatnaf, Sauka-Spengler, Tatjana, Higgs, Douglas R., Philipsen, Sjaak
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2020
Subjects:
Plenary Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7531998/
https://ncbi.nlm.nih.gov/pubmed/32396940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020004826
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