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The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators

Many genes and pathways have been linked to aging, yet our understanding of underlying molecular mechanisms is still lacking. Here, we measure changes in the transcriptome, histone modifications, and DNA methylome in three metabolic tissues of adult and aged mice. Transcriptome and methylome changes...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Bou Sleiman, Maroun, Jha, Pooja, Houtkooper, Riekelt, Williams, Robert W., Wang, Xu, Auwerx, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527782/
https://ncbi.nlm.nih.gov/pubmed/32997995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108203
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