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Confounding factors from inducible systems for spatiotemporal gene expression regulation

Spatiotemporally regulated targeted gene manipulation is a common way to study the effect of gene variants on phenotypic traits, but the Cre/loxP and Tet-On/Tet-Off systems can affect whole-organism physiology and function due to off-target effects. We highlight some of these adverse effects, includ...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Wüst, Rob C.I., Houtkooper, Riekelt H., Auwerx, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337492/
https://ncbi.nlm.nih.gov/pubmed/32428200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202003031
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