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Development of Noonan syndrome by deregulation of allosteric SOS autoactivation

Ras family proteins play an essential role in several cellular functions, including growth, differentiation, and survival. The mechanism of action of Ras mutants in Costello syndrome and cancers has been identified, but the contribution of Ras mutants to Noonan syndrome, a genetic disorder that prev...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Umutesi, Hope Gloria, Hoang, Hanh My, Johnson, Hope Elizabeth, Nam, Kwangho, Heo, Jongyun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2020
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7521655/
https://ncbi.nlm.nih.gov/pubmed/32753483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013275
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