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Development of Noonan syndrome by deregulation of allosteric SOS autoactivation
Ras family proteins play an essential role in several cellular functions, including growth, differentiation, and survival. The mechanism of action of Ras mutants in Costello syndrome and cancers has been identified, but the contribution of Ras mutants to Noonan syndrome, a genetic disorder that prev...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7521655/ https://ncbi.nlm.nih.gov/pubmed/32753483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013275 |
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