Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes

During alcohol consumption, the esophageal mucosa is directly exposed to high concentrations of ethanol (EtOH). We therefore investigated the response of normal human esophageal epithelial cell lines EPC1, EPC2 and EPC3 to acute EtOH exposure. While these cells were able to tolerate 2% EtOH for 8 h...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chandramouleeswaran, Prasanna M., Guha, Manti, Shimonosono, Masataka, Whelan, Kelly A., Maekawa, Hisatsugu, Sachdeva, Uma M., Ruthel, Gordon, Mukherjee, Sarmistha, Engel, Noah, Gonzalez, Michael V., Garifallou, James, Ohashi, Shinya, Klein-Szanto, Andres J., Mesaros, Clementina A., Blair, Ian A., Pellegrino da Silva, Renata, Hakonarson, Hakon, Noguchi, Eishi, Baur, Joseph A., Nakagawa, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510980/
https://ncbi.nlm.nih.gov/pubmed/32966340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239625
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