ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds

A polymorphic mutation in the acetaldehyde dehydrogenase 2 (ALDH2) gene has been epidemiologically linked to the high susceptibility to esophageal carcinogenesis for individuals with alcohol use disorders. Mice subjected to alcohol drinking show increased oxidative stress and DNA adduct formation in...

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Detalhes bibliográficos
Publicado no:Am J Cancer Res
Main Authors: Tanaka, Koji, Whelan, Kelly A, Chandramouleeswaran, Prasanna M, Kagawa, Shingo, Rustgi, Sabrina L, Noguchi, Chiaki, Guha, Manti, Srinivasan, Satish, Amanuma, Yusuke, Ohashi, Shinya, Muto, Manabu, Klein-Szanto, Andres J, Noguchi, Eishi, Avadhani, Narayan G, Nakagawa, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859883/
https://ncbi.nlm.nih.gov/pubmed/27186430
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