Molecular Mechanisms of Acetaldehyde-Mediated Carcinogenesis in Squamous Epithelium

Acetaldehyde is a highly reactive compound that causes various forms of damage to DNA, including DNA adducts, single- and/or double-strand breaks (DSBs), point mutations, sister chromatid exchanges (SCEs), and DNA–DNA cross-links. Among these, DNA adducts such as N(2)-ethylidene-2′-deoxyguanosine, N...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Mizumoto, Ayaka, Ohashi, Shinya, Hirohashi, Kenshiro, Amanuma, Yusuke, Matsuda, Tomonari, Muto, Manabu
Format: Artigo
Language:Inglês
Published: MDPI 2017
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618592/
https://ncbi.nlm.nih.gov/pubmed/28891965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18091943
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