Esophageal 3D organoids of MPV17(-/-) mouse model of mitochondrial DNA depletion show epithelial cell plasticity and telomere attrition

Esophageal squamous cell carcinoma (ESCC) is an aggressive cancer with late-stage detection and poor prognosis. This emphasizes the need to identify new markers for early diagnosis and treatment. Altered mitochondrial genome (mtDNA) content in primary tumors correlates with poor patient prognosis. H...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Guha, Manti, Srinivasan, Satish, Sheehan, Maura M., Kijima, Takashi, Ruthel, Gordon, Whelan, Kelly, Tanaka, Koji, Klein-Szanto, Andres, Chandramouleeswaran, Prasanna M., Nakagawa, Hiroshi, Avadhani, Narayan G.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817447/
https://ncbi.nlm.nih.gov/pubmed/31692873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27264
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