Disruption of Cytochrome c Oxidase Function Induces Warburg Effect and Metabolic Reprogramming

Defects in mitochondrial oxidative phosphorylation complexes, altered bioenergetics and metabolic shift are often seen in cancers. Here we show a role for the dysfunction of electron transport chain component, cytochrome c oxidase (CcO) in cancer progression. We show that genetic silencing of the Cc...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Srinivasan, Satish, Guha, Manti, Dong, Dawei W, Whelan, Kelly A, Ruthel, Gordon, Uchikado, Yasuto, Natsugoe, Shoji, Nakagawa, Hiroshi, Avadhani, Narayan G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703574/
https://ncbi.nlm.nih.gov/pubmed/26148236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.227
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